There is no end in sight to the now business as usual reality of drug shortages in medicine. Anesthesiology is hit particularly hard in the number of medications which are not being manufactured to meet demand. Here is a list of medications common to anesthesia practice which the FDA lists as being in short supply, and the reasons given. It contains the three most frequently administered medications in the practice of anesthesia: propofol, fentanyl and midazolam. Law Med points out that it is no coincidence that only drugs which are off patent and now generics seem to have shortages.
Alfentanil Injection Material shortage and increased demand.
Atracurium besylate Manufacturing delays.
Atropine Sulfate Injection Manufacturing delay and increased demand.
Bupivacaine Hydrochloride Injection Manufacturing delay.
Calcium Chloride Injection Manufacturing delay.
Chloroprocaine (Nesacaine) Injection Increased demand and manufacturing delay.
Etomidate Injection increased demand and manufacturing delay.
Fentanyl Citrate Injection Manufacturing delay causing increased demand.
Hydromorphone Hydrochloride Injection Material shortage, manufacturing delay, increased demand
Ketorolac Injection Manufacturing delay, material shortage, increased demand.
Lidocaine Hydrochloride Injection Manufacturing delay.
Lorazepam Injection Manufacturing delay, production discontinued, increased demand.
Metoclopramide Injection manufacturer delay.
Midazolam Injection Temporary suspension of manufacturing, Other manufacturer shortage/withdrawal; Manufacturing delay; Quality improvement activities.
Morphine Sulfate Injection Manufacturing delay.
Morphine Sulfate Injection (Preservative Free) Manufacturer delay.
Naloxone Injection Manufacturer delay causing increased demand.
Ondansetron Injection 2 mg/mL Temporary discontine manufacturinsg, discontinue manufacturing, increased demand.
Pancuronium Bromide Injection Manufacturing delay.
Propofol Injection Manufacturing delay and increased demand.
Sodium Bicarbonate Injection Manufacturing delay causing increased demand.
Sufentanil Injection Materials delay, manufacturing delay.
Vecuronium Injection Manufacturing delay, increased demand.supply, Anesthesia, fentanyl, drug shortages, FDA, propofol